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Contributors MNM wrote the first draft of the article. All authors contributed to the revision and writing of the article.
Funding The authors are supported by the British Heart Foundation (FS/19/46/34445, FS/14/78/31020, CH/09/002, RG/16/10/32375, RE/18/5/34216, CS/18/4/34074). DEN is the recipient of a Wellcome Trust Senior Investigator Award (WT103782AIA). MRD is supported by a Sir Jules Thorn Award for Biomedical Research 2015.
Competing interests None declared.
Patient and public involvement Patients and/or the public were involved in the design, or conduct, or reporting, or dissemination plans of this manuscript.
Patient consent for publication Not required.
Provenance and peer review Commissioned; internally peer reviewed.
Author note References which include a * are considered to be key references
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