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Menopause and hormone therapy in the 21st century: why promote transdermal estradiol and progesterone?
  1. Pierre-Yves Scarabin1,
  2. Marianne Canonico1,2,
  3. Geneviève Plu-Bureau3,
  4. Emmanuel Oger4
  1. 1 Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France
  2. 2 Paris-Saclay University, Paris-South University, UVSQ, Paris-Saclay, Île-de-France, France
  3. 3 Unité de Gynécologie Endocrinienne, Université de Paris, Paris, France
  4. 4 EA 7449 REPERES (Pharmacoepidemiology and Health Services Research), Université de Rennes, Rennes, France
  1. Correspondence to Professor Pierre-Yves Scarabin, Center for Research in Epidemiology and Population Health, INSERM, Villejuif 69372, France; pierre-yves.scarabin{at}

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To the Editor:

In their editorial,1 Gersh and Lavie describe the many ways that estradiol impacts cardiovascular health. In addition, the authors rightly question the findings of the Women’s Health Initiative among menopausal women using hormone therapy. Importantly, they emphasise the need for using the most physiological human-identical transdermal estradiol combined with natural progesterone. However, no information is given on …

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  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient and public involvement Patients and/or the public were not involved in the design, conduct, reporting or dissemination plans of this research.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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