Footnotes

• Contributors JK designed, wrote and edited the article.

• Funding This study was funded by the Academy of Finland, Sydäntutkimussäätiö, Kuopion Yliopistollinen Sairaala.

• Competing interests None declared.

• Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

• Patient consent for publication Not required.

• Provenance and peer review Commissioned; internally peer reviewed.