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Clinical introduction
A 14-year-old girl is referred for echocardiography prior to induction chemotherapy for acute T-lymphoblastic leukaemia with over 95% blasts and hyperleucocytosis >1 00 000 G/L.
Before induction chemotherapy, including anthracycline, a cardiology consultation with echocardiography was performed (figure 1). The global systolic LV function was normal with a LV ejection fraction at 65% using Simpson biplane method. The mitral flow showed diastolic dysfunction with high filling pressures (E/E′=23). The ECG showed deep T-waves inversion in the anterior leads. Our patient had no personal or family history suggesting any inherited cardiac disorder.
Echocardiography. (A) M-mode parasternal long …
Footnotes
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.
Patient consent for publication Not required.
Provenance and peer review Not commissioned; externally peer reviewed.
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