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Cardiac abnormality in a prechemotherapy assessment for leukaemia in a 14-year-old girl
  1. Arthur Gavotto1,
  2. Alice Gauthier2,
  3. Oscar Werner2,3
  1. 1 PhyMedExp, University of Montpellier, CNRS, INSERM, Monpellier, France
  2. 2 Department of Pediatric and Congenital Cardiology, Centre Hospitalier Regional Universitaire de Montpellier, Montpellier, France
  3. 3 Pediatric radiology, University hospital, Montpellier, France
  1. Correspondence to Dr Arthur Gavotto, Pediatric and Congenital Cardiology, Centre Hospitalier Regional Universitaire de Montpellier, Montpellier 34295, France; a-gavotto{at}

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Clinical introduction

A 14-year-old girl is referred for echocardiography prior to induction chemotherapy for acute T-lymphoblastic leukaemia with over 95% blasts and hyperleucocytosis >1 00 000 G/L.

Before induction chemotherapy, including anthracycline, a cardiology consultation with echocardiography was performed (figure 1). The global systolic LV function was normal with a LV ejection fraction at 65% using Simpson biplane method. The mitral flow showed diastolic dysfunction with high filling pressures (E/E′=23). The ECG showed deep T-waves inversion in the anterior leads. Our patient had no personal or family history suggesting any inherited cardiac disorder.

Figure 1

Echocardiography. (A) M-mode parasternal long …

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  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.