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The Authors’ reply: instantaneous pressure-flow relationships in aortic stenosis
  1. Rong Bing1,
  2. Haotian Gu2,
  3. David E Newby1,
  4. Phil Chowienczyk2,
  5. Marc Richard Dweck1
  1. 1 BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
  2. 2 BHF Centre of Research Excellence, King's College London, London, UK
  1. Correspondence to Dr Rong Bing, Centre for Cardiovascular Science, Univserity of Edinburgh, Edinburgh EH16 4SA, UK;{at}

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The Authors’ reply

We thank Professor Otto and Dr Bermejo for their interest and astute comments regarding our study.1

The echo frame for determining left ventricular volume at peak aortic velocity is estimated by the measuring the total number of frames from the R wave to the end systole and multiplying this by the fraction of time from the R wave to the peak aortic velocity and from the R wave to the end systole. In the initial report of EF1 in aortic stenosis (AS),2 the intraobserver and interobserver coefficients of variation were 6.7% and 9.8%. We acknowledge that EF1 …

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  • Contributors All authors contributed to this paper.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests HG and PC are named on a patent for the use of first phase ejection fraction (WO2017144851A1).

  • Patient and public involvement Patients and/or the public were not involved in the design, conduct, reporting or dissemination plans of this research.

  • Patient consent for publication Not required.

  • Provenance and peer review Commissioned; internally peer reviewed.

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