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Neoaortic growth rate and diameter as risk factors for neoaortic valve regurgitation after arterial switch operation
  1. Roel LF van der Palen1,
  2. Sara J Baart2,
  3. Nan van Geloven3,
  4. Mark G Hazekamp4,
  5. Nico A Blom1
  1. 1 Division of Pediatric Cardiology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
  2. 2 Department of Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
  3. 3 Department of Biomedical Data Sciences, Section Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands
  4. 4 Cardiothoracic Surgery, Leiden University Medical Center, Leiden, The Netherlands
  1. Correspondence to Dr Roel LF van der Palen, Division of Pediatric Cardiology, Department of Pediatrics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; r.vanderpalen{at}

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In our recently published article,1 neoaortic dimensions and neoaortic valve function derived from echocardiographic imaging were longitudinally assessed from birth until adulthood in 345 patients after arterial switch operation for transposition of the great arteries. From these data, neoaortic root dimensions were independently associated with the development of at least moderate neoaortic valve regurgitation (AR≥moderate) by time-dependent Cox-regression (TD-Cox) analysis. With this analysis, no significant association could be established for the development of AR≥mild, and no relationship between neoaortic annulus dimensions and AR of any severity could be determined.

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  • Contributors Concept and design of the study: RLFvdP, MGH and NAB. Acquisition and analysis of the data: RLFvdP and NAB. Drafting of the manuscript: RLFvdP. Statistical analysis: RLFvdP, SJB and NvG. Interpretation of data, critical revision of the manuscript and approval of the final version of the manuscript: all authors.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient and public involvement Patients and/or the public were not involved in the design, conduct, reporting or dissemination plans of this research.

  • Patient consent for publication Not required.

  • Provenance and peer review Commissioned; internally peer reviewed.

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