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Identifying patients likely to be readmitted after transcatheter aortic valve replacement
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  • Published on: 27 January 2020
    Biomarkers to enhance prognosis assessment in transcatheter aortic valve replacement: usefulness of CA125
    • Sergio García-Blas, Cardiologist Hospital Clínico Universitario de Valencia. Spain
    • Other Contributors:
      • Vicente Pernias, Cardiologist
      • Juan Sanchis, Cardiologist
      • Julio Nuñez, Cardiologist

    We have read with interest the review published by Goldsweig et al of predictors of readmission after transcatheter aortic valve replacement (TAVR) (1). We agree that identifying factors linked with a higher rate of readmission is of utmost importance. In this review, several clinical and procedural factors have been identified as predictors of adverse events after TAVR. However, the potential value of biomarkers for risk stratification in this setting has also been suggested in the literature. Several biomarkers have been tested for prognostic purposes; among them, we would like to highlight the role of Carbohydrate Antigen 125 (CA125). CA125 is a glycoprotein released by the mesothelial cells in response to increased hydrostatic pressures and/or inflammatory stimuli (2). Their levels are elevated in up to two-thirds of decompensated patients and correlated to parameters of clinical and echocardiographic congestion including pulmonary artery and right atrial pressures. Interestingly, its changes after discharge are strongly associated with the risk of adverse clinical events (2). In the setting of TAVR, baseline (pre-implant) CA125 levels were independent predictors of death and MACE (death, myocardial infarction, stroke, and readmission), even after adjusting for well-established prognostic factors, in an observational study (3). Interestingly, increases of CA125 at any time in the follow-up after TAVR were independently related to events, suggesting its usefulness not...

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    Conflict of Interest:
    None declared.