Statistics from Altmetric.com
The relationship between hormone status and cardiovascular disease (CVD) in women remains controversial. CVD mortality is higher in women who experience period cessation at a younger age but few studies have examined the effect of menopause on risk factors for CVD. With ageing, there is an increased prevalence and severity of conventional CVD risk factors, including elevated serum lipid levels, hypertension, diabetes and body size, making it challenging to determine whether hormonal changes at menopause are an independent risk factor for CVD in women, particularly because previous studies have largely been based on a cross-sectional study design. O’Keeffe and colleagues1 were able to examine the relationship between age at period cessation and trajectories of CVD risk factors using longitudinal data from 2547 women enrolled in the UK Medical Research Council National Survey of Health and Development, followed from birth in 1946 to the most recent visit at age 69 years. This data showed no association between age at period cessation (natural or surgical) and trajectories of serum lipid levels or blood pressure from age 36 to 69 years, with inconsistent associations for other CVD risk factors. This data suggests that the increased risk of adverse CVD outcomes with age in women is not mediated simply by changes in conventional CVD risk factors (figure 1).
In a compelling editorial, Gersh and Lavie2 suggest that loss of normal ovarian function, specifically oestrogen production, is the likely mechanism of increased CVD risk after menopause, highlighting the many ways in which oestrogen might protect against CVD (figure 2). Further, they argue that ‘The unintended legacy of the Women’s Health Initiative (WHI), which tested the wrong “hormones” (not human-identical and given orally), on the wrong subjects (too old), must now finally be ended. The large body of scientific data that shows the harms of ovarian senescence and the CV benefits derived from hormones must now override the negative data derived from the WHI.” They conclude: “More research is needed, but it is time now to acknowledge the impact of menopause - of ovarian senescence - on the cardiovascular health of women and treat them with physiological doses of human identical hormones, prior to the development of serious CVD sequela.”
In another article in this issue of Heart, Ducas and colleagues3 performed a systemic review and meta-analysis of pregnancy outcomes in women with valvular heart disease (VHD), identifying 12 studies with a total of 646 pregnancies. There was a very high rate of adverse events in pregnant women with severe mitral stenosis (death in 3%, pulmonary oedema in 37%, preterm birth rate 18%). Women with severe aortic stenosis also had high rates of adverse maternal and fetal outcomes (figure 3). Schmidt et al 4 acknowledge the challenges in caring for pregnant women with VHD but hope this data will be a ‘call for action’ to improve prenatal counselling, evaluation and treatment of women with VHD and to ensure that those with moderate to severe VHD are referred to centres with expertise in their management.
Three original research papers in this issue of Heart address sex differences in cardiac arrhythmias. In patients with an implanted cardiac defibrillator (ICD) a long-detection time for arrhythmia detection delivered fewer ICD therapies in women compared with men, suggesting that more arrhythmias self-terminated within 40 beats (compared with 24 beats with shorter detection times), with no sex difference in overall survival benefit of ICDs.5 In patients with atrial fibrillation (AF), the risk of ischaemic stroke varied with age in women compared with men, being lower in women under age 66 yearsn, not different in women age 66–75 years, and higher only in those over age 75 years, suggesting that the conventional scores for estimated stroke risk in AF patients might need to be modified.6 Women with heart failure and atrial fibrillation, are older, have different comorbidities fewer catheter ablations, and longer hospitalisations, although in-hospital mortality is similar compared with men after multivariable adjustment.7
A detailed review article by Mehilli and Presbitero8 discusses coronary artery disease and acute coronary syndrome in women, summarising the features specific to women in terms of risk factors, clinical presentations, diagnosis and findings on coronary angiography (figure 4).
Contributors All authors contributed.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Not required.
Provenance and peer review Commissioned; internally peer reviewed.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.