Article Text

Download PDFPDF
Ischaemic stroke in heart failure: back to basics?
  1. Adam J Nelson1,
  2. Manesh R Patel1,2
  1. 1 Duke Clinical Research Institute, Duke University, Durham, North Carolina, United States
  2. 2 Division of Cardiology, Duke University Health System, Durham, North Carolina, United States
  1. Correspondence to Dr Manesh R Patel, Duke University, Durham, NC 27708, USA; manesh.patel{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Approximately 2%–3% of patients with heart failure (HF) will sustain a stroke; an outcome considered by many to be worse than death.1 Not only are these events twofold to threefold more common in patients with HF, over half of the strokes are life-threatening or severely disabling2 and compared with the general population are associated with longer hospital stays and higher rates of mortality.3 Although atrial fibrillation (AF) and HF are linked and frequently coexist, HF has been increasingly recognised as an independent predictor of ischaemic stroke after adjusting for the presence of AF.4 There is biological plausibility with multiple lines of evidence linking HF to a prothrombotic state characterised by perturbations in all components of Virchow’s triad. Despite this translational understanding, considerably less is known about the stroke risk profile of patients with HF in sinus rhythm when compared with the detailed phenotyping of stroke risk of patients with both AF and HF.

Chou et al in their Heart paper provide important, additional insight into the burden of stroke and myocardial infarction (MI) that arise in the context of HF without AF.5 The authors studied administrative data from a random sampling of 1 000 000 beneficiaries covered under the Taiwan National Health Insurance Database (99% of the population ~23 million people). International Classification of Disease, Ninth Revision (ICD-9) codes were used to identify a cohort with newly diagnosed systolic HF and to exclude those with a prior history of stroke or MI. Those with diagnosis codes for AF or flutter at baseline or during follow-up were also excluded leaving a HF cohort of 12 179 individuals. A comparator non-HF cohort was propensity matched 1:1 by age, sex, monthly income, urbanisation and selected comorbidities. Over a collective follow-up period of approximately 150 000 person years, there were 1766 ischaemic strokes, 387 …

View Full Text


  • Twitter @ajnelson

  • Contributors The authors are the sole contributors to the editorial.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests AJN has nothing to disclose. MRP is on the advisory boards of Bayer and Janssen; and has received research grants from Bayer, Janssen, AstraZeneca, HeartFlow, the National Institutes of Health, and the National Heart, Lung, and Blood Institute.

  • Patient consent for publication Not required.

  • Provenance and peer review Commissioned; internally peer reviewed.

Linked Articles