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76 Prognostic potential of electrocardiographic parameters in patients with multiple myeloma
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  1. Guoliang Li1,
  2. Jie Wang1,
  3. Jiaqi An1,
  4. Gary Tse2,
  5. Pengcheng He1,
  6. Haibo Liu1,
  7. Aifeng Zhang3,
  8. Chaofeng Sun1,
  9. Yongxin Li1,
  10. Yang Yan1
  1. 1First Affiliated Hospital of Xi’an Jiaotong University
  2. 2Xiamen Cardiovascular Hospital, Xiamen University
  3. 3Brigham and Women’s Hospital, Harvard Medical School

Abstract

Background Patients with multiple myeloma (MM) can develop cardiac abnormalities, predisposing them to the development of heart failure, arrhythmia or infarction with poor prognosis. The purpose of this study is to evaluate the prognostic potential of electrocardiographic (ECG) parameters in patients with MM.

Methods This study retrospectively included patients with MM from January 2010 to December 2018 in the First Affiliated Hospital of Xi’an Jiao Tong University. Univariate and multivariate Cox proportional hazard models were conducted to evaluate the relationship between ECG parameters and all-cause mortality in patients with MM.

Results A total of 409 patients were included (mean age: 61.3 ± 9.7 years, 59.1% male). The relationship of ECG parameters, including PR interval, voltage, QRS axis, QRS duration and QTc interval, and all-cause mortality in patients with MM was evaluated. Overall, patients with QTc interval ≥ 400 msec have a significantly higher all-cause mortality compared to those with QTc interval <400 msec (P <0.001). When stratified by International Staging System (ISS), this relationship was true for stages II and III (P <0.01), but not stage I (P > 0.05). MM patients with QRS duration ≥ 120 msec had a higher all-cause mortality compared to those with QRS duration <120 msec for females (P <0.01) but not for males (P > 0.05). PR interval, voltage and QRS axis did not predict mortality.

Conclusions QTc interval was independently associated with all-cause mortality in MM patients, especially when QTc interval was more than 400 msec in more advanced stages II and III. ECG parameters may provide prognostic potential of MM patients and promote the management of patients with MM.

Conflict of Interest None

  • multiple myeloma
  • electrocardiography
  • mortality

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