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120 Coronary computed tomography versus stress echocardiography-guided management of stable chest pain patients: a propensity-matched analysis
  1. Anastasia Vamvakidou1,
  2. Oleksandr Danylenko1,
  3. Jiwan Pradhan2,
  4. Mihir Kelshiker2,
  5. Timothy Jones2,
  6. David Whiteside2,
  7. Amarjit Sethi3,
  8. Roxy Senior1
  1. 1Royal Brompton Hospital
  2. 2Northwick Park Hospital
  3. 3Ealing Hospital


Introduction Recent recommendations by national and international societies advocate the use of coronary computed tomography (CCT) as the first-line test for the assessment of low-risk patients with suspected stable angina. However limited real-life data exist regarding its relative clinical value versus stress echocardiography (SE)-guided management.

We aimed to assess in a real-life setting the clinical value of stress echocardiography (SE)-guided versus CCT-guided management in patients presenting with stable chest pain and no prior history of coronary artery disease (CAD).

Methods We compared the relative feasibility, efficacy and the proportion of patients undergoing downstream testing including revascularisation and their impact on outcome (mortality and myocardial infarction) when CCT versus SE were used as the first line test for the assessment of stable chest pain.

Of the patients who underwent CCT (N=2192) or SE (N=2081) between October 2013 and October 2014 only those with suspected stable angina and without previous CAD were selected. The population was propensity-matched (total 1980 patients-990 patients each group) to account for differences in the baseline cardiovascular risk factors (Figure 1).

Abstract 120 Figure 1 Schematic diagram of study population selection
ACS: Acute coronary syndrome, CAD: Coronary artery disease, CT: computed tomography, HOCM: Hypertrophic obstructive cardiomyopathy, LVEF: Left ventricular ejection fraction

Results The baseline characteristics of the propensity-matched population are shown in Table 1. The mean age of the population was 59±13.2 years and 949 (47.9%) patients were male. Inconclusive tests were 6% versus 3% (p<0.005) in CCT versus SE. Severe (>70%) luminal stenosis on CCT and inducible ischemia on SE detected obstructive CAD by invasive coronary angiography in 63% versus 57% patients (p=0.33). Over the entire follow-up period (median 717 (IQR 93-1069) days) significantly more patients underwent invasive coronary angiography (21.5% versus 7.3%, p<0.005) and revascularisation (33.5% versus 3.5%, p<0.005) respectively in the CCT versus the SE group (Table 2). Following their initial assessment 336 (33.9%) patients in the CCT and 86 (8.7%) in the SE group underwent further functional testing (SE, stress cardiac MRI, exercise electrocardiography) (p<0.005). There was no difference in all-cause mortality (p=0.26) or death and myocardial infarction (p=0.16) between the two groups (Table 2, Figure 2).

Abstract 120 Table 1 Baseline demographic and clinical characteristics of patients undergoing coronary CTa versus stress echocardiography in the propensity-matched populations
Abstract 120 Table 2 Incidence of invasive coronary angiography, revascularization death and major cardiac events in the propensity matched population
Abstract 120 Figure 2 Comparison of outcome (death and composite of myocardial infarction and death) following stress echocardiography versus coronary CT. CT: computed tomography, MI: Myocardial infarction

Conclusions SE when used for the assessment of patients with stable angina and no prior CAD resulted in more conclusive tests, similar detection of obstructive CAD, less overall invasive coronary angiography and revascularization and less subsequent functional tests compared with CCT. These findings suggest that SE may be considered an equally appropriate test compared to CCT in the assessment of low-risk patients with chest pain and no prior CAD.

Conflict of Interest None

  • Stable chest pain
  • Coronary Computed Tomography
  • Stress Echocardiography

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