Article Text

Download PDFPDF
Is global longitudinal strain a gold standard parameter in all cardiovascular diseases?
  1. Kenya Kusunose
  1. Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan
  1. Correspondence to Dr Kenya Kusunose, Cardiovascular Medicine, Tokushima University Hospital, Tokushima 7700003, Japan; kusunosek{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Since the development of speckle tracking echocardiography over 15 years ago, global longitudinal strain (GLS) has been applied in several cardiovascular diseases. Strain is an index of change in length between baseline length and length after deformation. It is important to recognise that GLS is a direct measurement of myocardial changes and different from left ventricular ejection fraction (LVEF), which is based on volume calculation. GLS is calculated by averaging multiple segments and overcomes the effects of partial noise and provides a robust marker of systolic function. Although the accuracy of GLS measurements depends on the experience of the observer, its variability is smaller and more reproducible than that of LVEF, even in the hands of inexperienced observers.1 Recently, artificial intelligence was reported to improve precision in strain measurements.2 Small measurement variability means that even a small difference is not a measurement error. According to these backgrounds, GLS can be used to monitor the LV function …

View Full Text


  • Contributors KK is the sole contributor.

  • Funding This work was supported by Takeda Science Foundation.

  • Competing interests None declared.

  • Patient and public involvement Patients and/or the public were not involved in the design, conduct, reporting or dissemination plans of this editorial.

  • Provenance and peer review Commissioned; internally peer reviewed.

Linked Articles