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Sodium-glucose co-transporter 2 inhibitor therapy: mechanisms of action in heart failure
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  • Published on:
    Sodium-glucose co-transporter 2 inhibitors with cellular anti-ischemics: A favorable combination in diabetic patients with cardiovascular disease
    • KENAN YALTA, Cardiologist Trakya University, Cardiology Department
    • Other Contributors:
      • UGUR OZKAN, Cardiologist
      • TULIN YALTA, Pathologist

    Sodium-glucose co-transporter 2 inhibitors with cellular anti-ischemics: A favorable combination in diabetic patients with cardiovascular disease

    Kenan YALTA, MD a
    Ugur OZKAN, MD a
    Tulin YALTA, MD b

    a,TrakyaUniversity, CardiologyDepartment, Edirne, TURKEY
    b,TrakyaUniversity, Pathology Department, Edirne, TURKEY
    Corresponding Author: Kenan YALTA Trakya University, CardiologyDepartment, Edirne, TURKEY
    Email-, Phone: 00905056579856

    Sodium-glucose co-transporter 2 (SGLT2) inhibitor therapy is a specific mode of anti-diabetic strategy that significantly improves cardiovascular outcomes (1). The recently published article by Joshi SS, et al (1) has focused on beneficial effects of SGLT2 inhibitors in the setting of heart failure (HF). We fully agree that complex cellular mechanisms, beyond diuresis (1), seem to underlie pleitrophic actions of these agents. More specifically, it also seems likely that SGLT2 inhibitors might potentiate favorable effects of certain metabolic agents including cellular anti-ischemics (and vice versa) in diabetic patients with cardiovascular disease. Accordingly, combination of SGLT2 inhibitors with cellular anti-ischemic regimens might have important implications in these patients:
    It is well known that free fatty a...

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    Conflict of Interest:
    None declared.