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- Published on: 28 July 2021
- Published on: 28 July 2021Sodium-glucose co-transporter 2 inhibitors with cellular anti-ischemics: A favorable combination in diabetic patients with cardiovascular disease
Sodium-glucose co-transporter 2 inhibitors with cellular anti-ischemics: A favorable combination in diabetic patients with cardiovascular disease
Kenan YALTA, MD a
Ugur OZKAN, MD a
Tulin YALTA, MD ba,TrakyaUniversity, CardiologyDepartment, Edirne, TURKEY
b,TrakyaUniversity, Pathology Department, Edirne, TURKEY
Corresponding Author: Kenan YALTA Trakya University, CardiologyDepartment, Edirne, TURKEY
Email- kyalta@gmail.com, akenanyalta@trakya.edu.tr Phone: 00905056579856Sodium-glucose co-transporter 2 (SGLT2) inhibitor therapy is a specific mode of anti-diabetic strategy that significantly improves cardiovascular outcomes (1). The recently published article by Joshi SS, et al (1) has focused on beneficial effects of SGLT2 inhibitors in the setting of heart failure (HF). We fully agree that complex cellular mechanisms, beyond diuresis (1), seem to underlie pleitrophic actions of these agents. More specifically, it also seems likely that SGLT2 inhibitors might potentiate favorable effects of certain metabolic agents including cellular anti-ischemics (and vice versa) in diabetic patients with cardiovascular disease. Accordingly, combination of SGLT2 inhibitors with cellular anti-ischemic regimens might have important implications in these patients:
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It is well known that free fatty a...Conflict of Interest:
None declared.