Objective The aim of this work is to assess the relationship between significant paravalvular leak (SPL) after transcatheter aortic valve implantation (TAVI) on anaemia and their impact on prognosis.
Methods Observational analytic study developed at two university hospitals, including all consecutive patients who underwent TAVI during a 10-year period (2009 to 2018). A logistic regression model was created to determine independent predictors of anaemia at 3 months. Time to event outcomes were analysed with Cox regression. Median follow-up was 21.3±21.9 months.
Results 788 patients were included. 5.3% had SPL. SPL was an independent predictor of anaemia 3 months after TAVI (OR: 8.31, 95% CI: 2.06 to 33.50). SPL and anaemia at 3 months were independently associated with long-term mortality (HR: 1.82, 95% CI: 1.16 to 2.85; HR: 2.07, 95% CI: 1.39 to 3.08).
Conclusion SPL is an independent predictor of anaemia at 3 months after TAVI, a condition that doubles long-term mortality. Our findings could explain in part the worse prognosis of SPL after TAVI. Further pathophysiological studies are necessary to explain this association.
- endovascular procedures for aortic and vascular disease
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Contributors JL-P, DL-O, JFOD, BIC and PJAM contributed to the conception or design of the work and final approval of the version to be published. JFOD, XCM, MP-P, AG-T, OOG, CCMP, CAF, LA-R, FGP and MJ contributed to the data collection. JL-P, DLO, MP-P, OOG, AGT and PJAM contributed to the data analysis and interpretation. JL-P and DLO drafted the article. AGT, JCSP, ABCA, RTN, JJAM, JRG-J and JFOD contributed to the critical revision of the article.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.
Patient consent for publication Not required.
Ethics approval Comite Autonómico de Ética da Investigación de Santiago ID: 2018/495.
Provenance and peer review Not commissioned; externally peer reviewed.
Data availability statement All data relevant to the study are included in the article or uploaded as supplementary information. For any other data contact: Email: firstname.lastname@example.org. Address: Servicio de Cardiología, Hospital Clínico Universitario de Santiago de Compostela, rúa da Choupana s/n, 15703, Santiago de Compostela, Galicia, España.
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