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Stroke risk in rheumatic heart disease
  1. Ganesan Karthikeyan
  1. Department of Cardiology, All India Institute of Medical Sciences, New Delhi 110029, India
  1. Correspondence to Dr Ganesan Karthikeyan, Department of Cardiology, All India Institute of Medical Sciences, New Delhi 110029, India; karthik2010{at}

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Cardiologists’ perception of the risk of stroke in rheumatic heart disease (RHD) is influenced more by anecdote and opinion than by the evidence.1 Despite data indicating a similar, if not a lower risk of stroke, even among the potentially highest-risk patients with RHD (those with mitral stenosis (MS) and atrial fibrillation (AF)),1 there is a pervasive belief that they may be at the ‘highest risk of thromboembolism’.2 As a consequence, in current practice, any patient with significant valvular heart disease and AF (valvular AF) becomes a candidate for long-term oral anticoagulation, without further risk stratification. The perception of very high stroke risk in RHD is also reinforced by estimates of stroke burden, which are based on extrapolation from the proportion of stroke admissions who have RHD (3%–8%),3 rather than the proportion of strokes attributable to RHD in the community (1%–2%).4 Contemporary data on stroke risk in RHD are therefore needed to realign risk perceptions to reality, to aid in risk stratification and to help make decisions on long-term anticoagulation. The study by Vasconcelos and colleagues in this issue of Heart is therefore a welcome addition to the literature in this area.5

Incidence, predictors and risk stratification

Patients with valvular AF have a risk of stroke similar to that of those with non-valvular AF. Data from the Framingham study showed that the absolute risk of stroke was 4.5 per 100 patient-years among patients with MS and AF, similar to the risk in those with non-valvular AF (4.2 per 100 patient-years).6 In passing, it is worth noting that most …

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  • Contributors GK is the sole author of this work.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient and public involvement Patients and/or the public were not involved in the design, conduct, reporting or dissemination plans of this research.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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