Footnotes

• Twitter @ramosnas

• Contributors Conception and design of the research: Nascimento, BR; Acquisition of data: Nascimento, BR, Sable, C; Analysis and interpretation of data: Nascimento, BR, Sable, C; Obtaining financing: Nascimento, BR, Sable, C; Writing of the manuscript: Nascimento, BR; Critical revision of the manuscript for intellectual content: Sable, C, Nascimento, BR; Authors responsible for the overall content as guarantors: Nascimento, BR, Sable, C.

• Funding BN is supported in part by Conselho Nacional de Desenvolvimento Científico e Tecnológico (Bolsa de produtividade em pesquisa, 312382/2019-7), by the Edwards Lifesciences Foundation (Improving the Prevention and Detection of Heart Valve Disease Across the Lifespan, 2021) and by Fundação de Amparo à Pesquisa do Estado de Minas Gerais (grant APQ-000627-20).

• Competing interests None declared.

• Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

• Provenance and peer review Commissioned; internally peer reviewed.