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A genetic diagnosis is of increasing importance in prevention of adverse events in patients with cardiovascular disease.1 For example, catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) is usually due to a pathogenic variant in cardiac ryanodine receptor 2 (RYR2) and is inherited in a familial autosomal dominant pattern, but sporadic cases also have been reported. In this issue of Heart, Shimamoto and colleagues2 compared 24 probands with familial inheritance of CPVT1 to 58 patients with de novo variants. In both groups, almost ½ the probands presented with syncope or cardiac arrest before a genetic diagnosis was known. Symptom onset occurred earlier in those with a de novo variant compared with those with familial inheritance (figure 1). In addition, symptoms occurred in only 37.5% of genotype-positive parents versus 66.7% of siblings with the pathogenic variant. The authors conclude: ‘Because two-thirds of the genotype-positive parents were asymptomatic and inheritance could not be predicted by their symptoms, genetic screening of parents and siblings in all CPVT1 cases may enable early diagnosis and prophylactic therapeutic intervention to prevent sudden cardiac death.’
In the accompanying editorial,3 Postema and van der Werf point out that although CPVT is rare, with an estimated prevalence of 1 in 10 000 individuals, this arrythmias syndrome is a cause of sudden cardiac death in children and young adults who are otherwise healthy (figure 2). They conclude that this study provides ‘new insights in CPVT showing that de novo pathogenic or likely pathogenic RYR2 variants are of very common occurrence in CPVT, often locate to the RYR2 C-terminus, and that these associate with a more malignant CPVT phenotype. In addition, this study once again shows that national and international collaborations are essential to perform valuable studies in such rare and malignant arrhythmia syndromes.’
In this issue of Heart, the joint British Societies guidelines4 for cardiac multidisciplinary team meetings (MDMs) are published online and accompanied by an summary editorial by Lindman and Goel.5 MDMs are recommended for patients being considered for myocardial revascularisation, aortic valve disease, mitral and tricuspid valve disease and endocarditis. Many patients can be rapidly triaged by the MDM but some will require detailed review. Ideally, MDMs should be virtual (or hybrid) to include all members of the team and allow participation by referring clinicians. The principles of patient-centred care and shared decision making are core to the MDM process, which should be documented in the medical record. As Lindman and Goel5 conclude: ‘With a multidisciplinary Heart Team evaluation now widely recommended and no longer a novel concept, the British working group has provided helpful guidance for how the Heart Team does its work. Other countries should follow suit in a way that incorporates regional particulars relevant to the optimal implementation of foundational principles (figure 3). And, in all locations, further studies and efforts are needed to refine, update and disseminate best practices in multidisciplinary Heart Team evaluation motivated by the overarching objective to treat the right patient at the right time with the right therapy.’
Adding to the evidence that aortic stenosis (AS) is more common than previously recognised, Stewart and colleagues6 report data from Australia on over 90 000 men and women with a mean age about 60 years who had two echocardiograms at least 2 years apart. Overall, 6.9% developed AS within 5 years. In addition, there was a higher risk of all-cause mortality with any degree of AS, ranging from 1.42-fold for mild AS to 2.27-fold for severe AS (median follow-up 7.7 years), emphasising the importance of periodic surveillance once AS is diagnosed.
Despite the wide-spread use of numeric scores to estimate risk in patients presenting with chest pain, we should not underestimate the value of physician judgement. In an analysis of 4533 patients from the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) Trial, Fordyce and colleagues7 found that physician risk estimated correlated poorly with Diamond-Forrester and European Society of Cardiology (ESC) pretest probability (PTP) estimates. However, only the physician estimates were associated with a higher incidence of adverse cardiovascular outcomes. Villines and Weber8 suggest it is ‘time to move on from pretest probably scores for stable chest pain’ (figure 4). As they succinctly conclude: ‘In the future, it is likely that artificial intelligence will improve PTP estimates, harnessing the sizeable amount of clinical and imaging information available on many patients. For now, we believe that the field of cardiovascular medicine should consider moving beyond rigid pretest probability approaches that anchor primarily on age, sex and classifications of angina typicality and trust the power in physician judgement.’
The Education in Heart article9 in this issue provides an overview of cardiac resynchronisation therapy (CRT) including indications, effect on clinical outcomes, and optimisation of patient benefit. They conclude that although biventricular CRT provides benefit in heart failure patients with a wide QRS due to left bundle branch block, CRT has a less clear role with other QRS morphologies. Alternate approaches under investigation include delivering CRT via the His or left bundle to provide conduction system pacing.
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Footnotes
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.