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Twitter @DrJHoward, @profdfrancis
Contributors JPH and DPF conceived, drafted and revised the work and have given final approval for the version to the published.
Funding JPH is supported by the Wellcome Trust (212183/Z/18/Z).
Competing interests None declared.
Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.
Provenance and peer review Commissioned; externally peer reviewed.
Author note References which include a * are considered to be key references.