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We read with great interest the article titled “Premature ventricular complexes and development of heart failure in a community-based population” by Limpitikul’s team. The study by Limpitikul et al. indicates that coupling interval heterogeneity was an independent risk factor suggests that the mechanism of premature ventricular complexes(PVC) generation may influence the risk of heart failure. The prospective study of Limpitikul et al. overcomes the referral bias of previous cross-sectional studies, but there are some questions with this study. We did not see the description of the number of Holter tests in the article, so we think that maybe all the people included in the study only performed Holter once. However, the results of a single Holter monitoring may be affected by many factors. For example, unhealthy lifestyles such as mental stress, overwork, excessive smoking, alcohol, and coffee intake can all induce PVC. In view of the fact that any factor leading to premature depolarization of ventricular muscles can be the cause of PVC, we believe that the conclusion of follow-up 11 years later based on the results of a Holter is not very credible.