Footnotes

• Twitter @jlampre

• Contributors All authors contributed to the drafting of the manuscript.

• Funding JLM is supported by NHLBI grant 1K99HL157721-01A1.

• Competing interests JLM reports receiving research support from Bayer pharmaceuticals unrelated to the present work. PN reports investigator-initiated grants from Amgen, Apple, AstraZeneca, Boston Scientific, and Novartis, personal fees from Apple, AstraZeneca, Blackstone Life Sciences, Foresite Labs, Novartis, Roche/Genentech, and TenSixteen Bio, is a scientific advisory board member of Esperion Therapeutics, geneXwell, and TenSixteen Bio, shareholder of geneXwell and TenSixteen Bio, and spousal employment at Vertex, all unrelated to the present work.

• Provenance and peer review Commissioned; internally peer reviewed.