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Contributors All authors contributed to the drafting of the manuscript.
Funding JLM is supported by NHLBI grant 1K99HL157721-01A1.
Competing interests JLM reports receiving research support from Bayer pharmaceuticals unrelated to the present work. PN reports investigator-initiated grants from Amgen, Apple, AstraZeneca, Boston Scientific, and Novartis, personal fees from Apple, AstraZeneca, Blackstone Life Sciences, Foresite Labs, Novartis, Roche/Genentech, and TenSixteen Bio, is a scientific advisory board member of Esperion Therapeutics, geneXwell, and TenSixteen Bio, shareholder of geneXwell and TenSixteen Bio, and spousal employment at Vertex, all unrelated to the present work.
Provenance and peer review Commissioned; internally peer reviewed.