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Contributors MCW wrote the original draft. MCW and DEN performed critical review and editing of the manuscript.
Funding MCW (FS/ICRF/20/26002) and DEN (CH/09/002, RG/16/10/32375, RE/18/5/34216) are supported by the British Heart Foundation. DEN is the recipient of a Wellcome Trust Senior Investigator Award (WT103782AIA). MCW is supported by The Chief Scientist Office of the Scottish Government Health and Social Care Directorates (PCL/17/04).
Competing interests DEN is the Principal Investigator and MCW is member of the steering committee of the SCOT-HEART trial. DEN and MCW have published research using the AutoPlaque software. MCW has received honoraria from Canon Medical Systems.
Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.
Provenance and peer review Commissioned; internally peer reviewed.