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Bicuspid aortic valve: evolving knowledge and new questions
  1. Byung Joo Sun1,
  2. Jae-Kwan Song2,3
  1. 1 Division of Cardiology, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, South Korea
  2. 2 Valvular Heart Disease Center, Asan Medical Center Heart Institute, Seoul, South Korea
  3. 3 Research Institute for Valvular Heart Disease, University of Ulsan College of Medicine, Seoul, South Korea
  1. Correspondence to Dr Jae-Kwan Song, Research Institute for Valvular Heart Disease, University of Ulsan College of Medicine, Asan Medical Center Heart Institute, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea; jksong{at}


Bicuspid aortic valve (BAV), a common congenital anomaly with various morphological phenotypes, is also characterised by marked heterogeneity in clinical presentations including clinically silent condition with mild valvulo-aortopathy, progressive valvulopathy and complex valvulo-aortopathy with shorter life expectancy. The clinical importance of using a general and unified nosology for BAV is well-accepted by opinion leaders and an international consensus statement has been recently published, which will serve as an important scientific platform for BAV. This review describes the current knowledge of BAV based on clinical studies, addresses several unresolved issues requiring investigators’ attention and highlights the necessity of prospective studies with a very long follow-up duration for better appreciation of BAV-associated valvulo-aortopathy. In addition, the progression of valvular calcification in patients with BAV and its potential contribution to development of valvulopathy will be discussed.

  • bicuspid aortic valve
  • aortic dissection
  • aortic stenosis
  • aortic regurgitation
  • aortic aneurysm

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  • Contributors BJS prepared the first draft of the manuscript and J-KS revised it critically for important intellectual content and approved the final manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Commissioned; externally peer reviewed.

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