Trimethylamine-N-oxide is associated with cardiovascular mortality and vascular brain lesions in patients with atrial fibrillation

Marco Luciani; Daniel Müller; Chiara Vanetta; Thamonwan Diteepeng; Arnold von Eckardstein; Stefanie Aeschbacher; Nicolas Rodondi; Giorgio Moschovitis; Tobias Reichlin; Tim Sinnecker; Jens Wuerfel; Leo H Bonati; Seyed Soheil Saeedi Saravi; Patricia Chocano-Bedoya; Michael Coslovsky; Giovanni G Camici; Thomas F Lüscher; Michael Kuehne; Stefan Osswald; David Conen; Jürg Hans Beer

doi:10.1136/heartjnl-2022-321300

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Trimethylamine-N-oxide is associated with cardiovascular mortality and vascular brain lesions in patients with atrial fibrillation

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Marco Luciani Department of Medicine, Baden Cantonal Hospital, Baden, Switzerland Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland PubMed articles Google scholar articles
Daniel Müller Institute of Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland Laboratory Medicine, University of Basel, Basel, Switzerland PubMed articles Google scholar articles
Chiara Vanetta Seminar for Statistics, ETH Zurich, Zurich, Switzerland PubMed articles Google scholar articles
Thamonwan Diteepeng Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland PubMed articles Google scholar articles
Arnold von Eckardstein Institute of Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland PubMed articles Google scholar articles
Stefanie Aeschbacher Cardiovascular Research Institute, University Hospital Basel, Basel, Switzerland Cardiology Division, University Hospital Basel, Basel, Switzerland PubMed articles Google scholar articles
Nicolas Rodondi Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland Department of General Internal Medicine, Inselspital University Hospital Bern, Bern, Switzerland PubMed articles Google scholar articles
Giorgio Moschovitis Division of Cardiology, Ospedale Regionale di Lugano-Civico e Italiano, Lugano, Switzerland PubMed articles Google scholar articles
Tobias Reichlin Department of Cardiology, Inselspital Universitatsspital Bern, Bern, Switzerland PubMed articles Google scholar articles
Tim Sinnecker Department of Neurology and Stroke Center, University Hospital Basel, Basel, Switzerland Medical Image Analysis Center (MIAC), Basel, Switzerland PubMed articles Google scholar articles
Jens Wuerfel Medical Image Analysis Center (MIAC), Basel, Switzerland Department of Biomedical Engineering, University of Basel, Basel, Switzerland PubMed articles Google scholar articles
Leo H Bonati Department of Neurology and Stroke Center, University Hospital Basel, Basel, Switzerland Research Department, Reha Rheinfelden, Rheinfelden, Switzerland PubMed articles Google scholar articles
Seyed Soheil Saeedi Saravi Department of Medicine, Baden Cantonal Hospital, Baden, Switzerland Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland PubMed articles Google scholar articles
Patricia Chocano-Bedoya Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland Population Health Laboratory, University of Fribourg, Fribourg, Switzerland PubMed articles Google scholar articles
Michael Coslovsky Cardiology Division, University Hospital Basel, Basel, Switzerland Department of Clinical Research, University Hospital Basel, Basel, Switzerland PubMed articles Google scholar articles
Giovanni G Camici Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland PubMed articles Google scholar articles
Thomas F Lüscher Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland Department of Cardiology, Royal Brompton and Harefield Hospitals Trust, London, UK National Heart and Lung Institute, Imperial College, London, UK PubMed articles Google scholar articles
Michael Kuehne Cardiovascular Research Institute, University Hospital Basel, Basel, Switzerland Cardiology Division, University of Basel Hospital, Basel, Switzerland PubMed articles Google scholar articles
Stefan Osswald Cardiovascular Research Institute, University Hospital Basel, Basel, Switzerland Cardiology Division, University of Basel Hospital, Basel, Switzerland PubMed articles Google scholar articles
David Conen Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada PubMed articles Google scholar articles
Jürg Hans Beer Department of Medicine, Baden Cantonal Hospital, Baden, Switzerland Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland PubMed articles Google scholar articles
SWISS-AF Investigators
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Correspondence to Professor Jürg Hans Beer, Department of Medicine, Cantonal Hospital of Baden, Baden Cantonal Hospital, Baden, 5404, Switzerland; hansjuerg.beer{at}ksb.ch

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Citation

Luciani M, Müller D, Vanetta C SWISS-AF Investigators, et al

Trimethylamine-N-oxide is associated with cardiovascular mortality and vascular brain lesions in patients with atrial fibrillation

Heart 2023;109:396-404.

Publication history

Received May 16, 2022
Accepted November 17, 2022
First published January 2, 2023.

Online issue publication

February 14, 2023

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