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The Authors’ reply
We would like to thank the careful reading by Marateb et al 1 of our article on the frequency and prognostic value of ECG findings in patients hospitalised with COVID-19,2 a substudy of the World Heart Federation Global COVID-19 Study.3 4 Before answering the specific points raised by the authors, we should clarify some general aspects. Our study does not intend to fill the gaps pointed out by the US Preventive Services Task Force,5 as suggested by the authors. This task force concluded that current evidence is insufficient to define the ‘benefits and harms of screening with resting or exercise ECG to prevent cardiovascular disease (CVD) events in asymptomatic adults at intermediate or high risk of CVD events’.5 We proposed studying the prognostic value of ECG findings in patients hospitalised with COVID-19, that is, hospitalised patients with an acute illness and not asymptomatic, ambulatory patients.
A second general issue is that Marateb and Mañanas considered that we intended to build or validate a clinical prediction model, defined in the TRIPOD statement as a tool ‘that combines multiple predictors by assigning relative weights to each predictor to obtain a risk or probability’ for diagnosis or prognostication, to aid healthcare providers in the decision-making.6 However, we just aimed to ‘prospectively evaluate the prognostic value of major ECG abnormalities in patients hospitalised with COVID-19 in a comprehensive pancontinental study’ …
Twitter @MarceloMartinsP, @tomribeiroecg
Contributors All authors contributed to further analysis and interpretation of the data, writing the response and reviewing the final text.
Funding The WHF COVID-19 Global Cardiovascular Disease Study is funded by WHF and unconditional research grant by Sanofi and Pfizer. The study was conducted independently without any direct involvement of the funders. The funding agencies were not involved in the study design, conduct, analysis or reporting of the results or manuscript preparation. ALPR s supported in part by CNPq (310790/2021-2 and 465518/2014-1), by FAPEMIG (PPM-00428-17 and RED-00081-16) and CAPES (88887.507149/2020-00).
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.
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