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123 Efficacy and safety of cardiac resynchronization therapy in chemotherapy-induced cardiomyopathy: a systematic review
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  1. Jahanzeb Malik
  1. Cardiovascular Analytics Group

Abstract

Objective With the increasing incidence of chemotherapy-induced cardiomyopathy (CIC), assessment of the cardiac resynchronization therapy (CRT) should be assessed

Methods The association of cardiac resynchronization therapy (CRT) with improvement in clinical outcomes, echocardiographic parameters, and New York Heart Classification (NYHA) class was assessed through this qualitative systematic review.

Results The 5 studies included a total of 169 patients who underwent CRT after CIC, and of these, 61 (36.1%) patients were males. All studies showed an improvement in left ventricular ejection fraction (LVEF), among other echocardiographic parameters of LV volume. However, these findings are limited by short follow-up periods, small sample sizes, and the absence of a control group.

Conclusion CRT was associated with improvement in all echocardiographic parameters, including LVEF, reduction in LV volumes, and NYHA class. The findings are limited by the small sample size, short follow-up, and absence of a control group.

Abstract 123 Figure 1

Identification of studies via databases and registers

Conflict of Interest none

  • CRT
  • chemotherapy
  • cardiomyopathy

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