Article Text

Download PDFPDF

Do specific HLA antigens predispose to ischaemic heart disease or idiopathic dilated cardiomyopathy?
  1. S. C. Grant,
  2. S. Sheldon,
  3. P. A. Dyer,
  4. R. D. Levy,
  5. N. H. Brooks
  1. Department of Cardiology, Wythenshawe Hospital, Manchester.


    BACKGROUND--The aetiology of idiopathic dilated cardiomyopathy is believed to have an immunological component. Association with human leucocyte antigens (HLAs) has been previously reported, particularly with HLA-DR4. AIM--To determine the association of HLA type with diagnosis in a group of patients assessed for heart transplantation. METHODS--A comparison was made of frequencies of HLA types in patients with a diagnosis of idiopathic dilated cardiomyopathy or (n = 98) ischaemic heart disease (n = 170) and in controls from the North Western region (n = 857). RESULTS--Neither the patients with idiopathic dilated cardiomyopathy nor those with ischaemic heart disease showed a significant increase or decrease in any HLA frequency compared with the controls. CONCLUSION--These results suggest that there is no HLA association with idiopathic dilated cardiomyopathy or ischaemic heart disease. This conflicts with the results of some previous studies.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.