Article Text

Download PDFPDF
Granulocyte colony stimulating factor in neutropenic patients with infective endocarditis
  1. Birgitte Molke Borgbjerg,
  2. Doris Hovgaard,
  3. Jørn Bech Laursen,
  4. Jan Aldershvile
  1. Medical Department B, Division of Cardiology, 2142 Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark
  1. Dr Borgbjerg.

Abstract

A well known complication in the treatment of infectious endocarditis is development of neutropenia caused by treatment with antibiotics in high concentrations over long periods. Neutropenia often necessitates discontinuation of antibiotic treatment. Three patients with infectious endocarditis who developed neutropenia are reported. The patients were treated with granulocyte colony stimulating factor (G-CSF), a haematopoietic growth factor that stimulates neutrophils. G-CSF induced an immediate increase in white blood cell count, primarily neutrophils. G-CSF may be effective in ameliorating neutropenia in patients who receive antibiotics for treatment of infectious endocarditis.

  • granulocyte colony stimulating factor
  • neutropenia
  • endocarditis

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.