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Histological findings in non-hypertrophic cardiomyopathy associated with Noonan’s syndrome
  1. N CARY
  1. S LARGE
  1. Senior Lecturer in Cardiology,
  2. Guy’s and St Thomas Hospitals,
  3. London, UK
  4. Consultant Histopathologist,
  5. Papworth Hospital,
  6. Cambridge, UK
  7. Consultant Transplant Surgeon,
  8. Papworth Hospital

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Sir,—We have reported the clinical and echocardiographic findings in a family with Noonan’s syndrome and a non-hypertrophic cardiomyopathy with restrictive physiology.1 The original proband has now had cardiac transplantation and we are able to report the histological findings. There was extensive, patchy fibrosis with many areas of myocyte disarray. There was also variability in the size of …

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