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Familial and primary cardiac amyloidosis: echocardiographically similar diseases with distinctly different clinical outcomes
  1. M HONGO,
  1. The First Department of Internal Medicine,
  2. Shinshu University School of Medicine,
  3. Matsumoto 390, Japan

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Sir,—In a recent issue, Dubrey et al reported interesting data concerning echocardiographic and electrocardiographic features in relation to the clinical outcome in two types of systemic amyloidosis: primary (AL) and familial.1 They pointed out that despite indistinguishable echocardiographic findings, including comparable ventricular wall thickening, patients with familial amyloid polyneuropathy (FAP) had a lower incidence of heart failure and low voltage on ECG, as well as longer one year survival, compared with patients with AL amyloidosis. Based on these results, …

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