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Sinus bradycardia and multiple episodes of sinus arrest following administration of ibutilide
  1. N B Amina,
  2. S Borzakb,
  3. S Housholderc,
  4. J E Tisdaled
  1. aDepartment of Pharmacy Services, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, Michigan 48202, USA, bDivision of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Henry Ford Hospital, cDepartment of Nursing, Henry Ford Hospital, dDepartment of Pharmacy Practice, College of Pharmacy and Allied Health Professions, Wayne State University, 230 Shapero Hall, Detroit, MI 48202, USA
  1. Dr Tisdale.

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Ibutilide is a Vaughan-Williams class III antiarrhythmic agent used for conversion of recent onset atrial flutter and fibrillation.1 We present the first case report of multiple sinus arrest episodes following administration of ibutilide in a patient with latent sinus node dysfunction.

A 79 year old woman with a history of hypertension, angina, and heart failure presented to the emergency department with exacerbation of heart failure. Medications before admission included metoprolol, digoxin, nitroglycerin, and aspirin.

On day 6, she complained of pleuritic pain radiating to the left arm and neck. Electrocardiography revealed atrial fibrillation with intermittent periods of atrial flutter. She became tachypnoeic with …

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