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Outcomes of transposition of the great arteries in the era of atrial inflow correction
  1. D Birniea,
  2. A Tometzkib,
  3. J Curzioa,
  4. A Houstonb,
  5. S Hooda,
  6. L Swana,
  7. W Doigb,
  8. N Wilsonb,
  9. M Jamiesonb,
  10. J Pollockb,
  11. W S Hillisa
  1. aDepartment of Medicine and Therapeutics, Glasgow University, Western Infirmary, Glasgow, UK, bDepartments of Cardiology and Cardiothoracic Surgery, Royal Hospital for Sick Children, Yorkhill, Glasgow, UK
  1. Dr D Birnie, Department of Medical Cardiology, Queen Elizabeth Building, Glasgow Royal Infirmary, Alexandra Parade, Glasgow G31 2ER, UK.


Objective To examine long term morbidity and mortality following atrial inflow corrective procedures for transposition of the great arteries (TGA) and to investigate factors that influence morbidity and mortality.

Design Retrospective cohort study from a single centre.

Setting Cardiology and cardiothoracic surgical unit in a large tertiary referral centre.

Patients All 130 patients who had TGA diagnosed between August 1972 and May 1988 and were considered suitable for atrial inflow correction; 109 of these underwent surgery (operative cohort: 84 Mustard operations and 25 Senning operations); 95 survived to hospital discharge (hospital surviving cohort).

Main outcome measures Death and cardiac events.

Results There were relatively good long term results from atrial inflow correction for TGA with 5, 10, and 15 year survivals of 77.3%, 75.9%, and 71.3%. However, there was an appreciable incidence of late cardiac death and events, with 5, 10, and 15 year cardiac event-free survivals of 74.5%, 67.1%, and 39.6%. Supraventricular tachycardia was the only significant risk factor for late cardiac death (relative risk 8.72, 95% confidence interval, 2.86 to 26.64). Senning patients had better event-free survival (p = 0.04).

Conclusions Atrial inflow correction for TGA has a reasonably good 15 year survival (71.3%), but there is an appreciable incidence of late cardiac deaths and events (15 year event-free survival 39.6%). The Senning procedure is preferable to the Mustard procedure for cases unsuitable for arterial switching.

  • transposition of the great arteries
  • congenital heart disease
  • Mustard operation
  • Senning operation

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