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Case report
Brugada syndrome associated with an autonomic disorder
  1. M Nomuraa,
  2. T Nadaa,
  3. J Endoa,
  4. Y Kondoa,
  5. M Yukinakaa,
  6. K Saitoa,
  7. S Itoa,
  8. H Moria,
  9. Y Nakayab,
  10. H Shinomiyac
  1. aSecond Department of Internal Medicine, School of Medicine, University of Tokushima, 2–50 Kuramoto-cho, Tokushima 770–8503, Japan, bDepartment of Nutrition, School of Medicine, University of Tokushima,, cMuskat Naika Clinic, 11–53 Yokosu-cho, Komatsushima, Tokushima 773-0006, Japan
  1. Dr Nomura.

Abstract

A 44 year old man with Brugada syndrome and ventricular fibrillation had an autonomic disorder, shown by spectral analysis of heart rate variability and 123I-MIBG myocardial scintigraphy. Periodic variation of the ST segments was detected by Holter ECG. Increased high frequency power (0.15–0.40 Hz), an index of parasympathetic nerve activity, was observed just before ST segment elevation. In addition, local dysfunction of sympathetic nerves in the left ventricle was detected by 123I-MIBG myocardial scintigraphy. Unbalanced autonomic nerve function plays an important role in inducing Brugada-type ECG signs.

  • Brugada syndrome
  • autonomic disorder
  • 123I-MIBG myocardial scintigraphy

https://doi.org/10.1136/hrt.80.2.194

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