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Preliminary report
Effect of an α2 agonist (mivazerol) on limiting myocardial ischaemia in stable angina
  1. K Foxa,
  2. H J Dargieb,
  3. D P de Bonoc,
  4. M F Oliverd,
  5. E Wülferte,
  6. T Kharkevitche
  1. aDepartment of Cardiology, Royal Brompton and Harefield NHS Trust, London, UK, bClinical Research Initiative in Heart Failure, University of Glasgow, Glasgow, UK, cFaculty of Medicine, Clinical Sciences Wing, Glenfield General Hospital, University of Leicester, Leicester, UK, dCardiac Medicine, National Heart & Lung Institute, Imperial College of Science, Technology and Medicine, Dovehouse Street, London SW3 6LY, UK, eResearch and Development, Cardiovascular Department, UCB SA Pharma Sector, Braine-l’Alleud, Belgium
  1. Professor Oliver.

Abstract

A specific α2 agonist, mivazerol, known to be effective in reducing myocardial ischaemia when given intravenously immediately before an exercise tolerance test, produced a significant increase in exercise duration and time to the onset of angina when given orally over a two week period to 25 patients with stable angina. A non-significant trend to reduction in electrocardiographic signs of ischaemia was also noted. The clinical relevance of this improvement now needs to be tested in larger numbers.

  • α2 agonist
  • sympathetic activity
  • myocardial ischaemia
  • stable angina
  • exercise tolerance test

https://doi.org/10.1136/hrt.82.3.383

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