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Effect of an α2 agonist (mivazerol) on limiting myocardial ischaemia in stable angina


A specific α2 agonist, mivazerol, known to be effective in reducing myocardial ischaemia when given intravenously immediately before an exercise tolerance test, produced a significant increase in exercise duration and time to the onset of angina when given orally over a two week period to 25 patients with stable angina. A non-significant trend to reduction in electrocardiographic signs of ischaemia was also noted. The clinical relevance of this improvement now needs to be tested in larger numbers.

  • α2 agonist
  • sympathetic activity
  • myocardial ischaemia
  • stable angina
  • exercise tolerance test

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