A specific α2 agonist, mivazerol, known to be effective in reducing myocardial ischaemia when given intravenously immediately before an exercise tolerance test, produced a significant increase in exercise duration and time to the onset of angina when given orally over a two week period to 25 patients with stable angina. A non-significant trend to reduction in electrocardiographic signs of ischaemia was also noted. The clinical relevance of this improvement now needs to be tested in larger numbers.
- α2 agonist
- sympathetic activity
- myocardial ischaemia
- stable angina
- exercise tolerance test
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Professor de Bono died since this article was submitted for publication.
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