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Trends in the provision of thrombolytic treatment between 1993 and 1997
  1. J S Birkhead on behalf of the Myocardial Infarction Audit Group
  1. Department of Cardiology, Northampton General Hospital, Northampton NN1 5BD, UK
  1. Dr Birkhead


OBJECTIVE To evaluate trends in provision of thrombolytic treatment between 1993 and 1997.

DESIGN Observational study.

SUBJECTS 3714 patients in 15 UK hospitals who had an admission diagnosis of myocardial infarction.

MAIN OUTCOME MEASURES Changes in prehospital and hospital delay before thrombolytic treatment; use of emergency services.

RESULTS Between 1993 and 1997 the proportion of patients who called for help within 30 minutes of the onset of symptoms fell from 42.6% to 36.0%; difference 6.6% (95% confidence intervals (CI) 3.3% to 10%). The direct use of the emergency service by patients and by doctors sending an ambulance without seeing the patient increased by 18.9%. Patients given thrombolytic treatment within 90 minutes of calling for help increased from 28.2% to 39.1%; difference 10.9% (95% CI 7.2% to 14.7%). Over the same period the proportion of patients treated in emergency departments increased from 4.4% to 17.3%, and the median delay from arrival to treatment in emergency departments fell from 53 to 36 minutes. Median delays for patients treated in cardiac care units after assessment in the emergency department fell from 63 to 54 minutes.

CONCLUSION Between 1993 and 1997 there was an increase in the proportion of patients with definite infarction having thrombolytic treatment within 90 minutes of a call for help. This was mainly the result of greater use of the emergency service and more rapid treatment of a larger proportion of eligible patients in emergency departments. Longer delays by patients have cancelled out some of this improvement.

  • myocardial infarction
  • thrombolytic treatment

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