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Coronary disease
Acute coronary syndromes: risk stratification
  1. Adam Timmis
  1. Department of Cardiology Royal Hospitals NHS Trust, London, UK
  1. Dr Adam D Timmis, Royal Hospitals Trust (London Chest Hospital), Bonner Road, London E2 9JX, UK email:adam{at}

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Risk stratification in acute coronary syndromes aims to identify those patients at greatest risk of recurrent ischaemic events who might benefit prognostically from further investigation and treatment. Unfortunately, however, none of the clinical or investigative markers currently available has sufficient diagnostic power to identify all high risk patients while excluding those at negligible risk. Moreover, for patients judged to be at high risk, the value of specific treatment may be poorly defined. Nevertheless, high event rates and finite facilities for invasive management emphasise the clinical and logistical importance of risk stratification which should play a central role in the management of acute coronary syndromes.

What is the risk and when is it greatest?

Our own database in east London shows that about 30% of patients with acute myocardial infarction and 20% with unstable angina experience a major event (death or non-fatal coronary syndrome) during the first year after hospital admission. Risk, however, is not a linear function of time, and as fig 1 shows, 66% of all major events during the first six months after myocardial infarction occur in the first 30 days. Moreover, the determinants of risk may change with time, acute phase arrhythmias and myocardial rupture in the first 48 hours giving way to reinfarction, heart failure, and secondary arrhythmias later after presentation. Thus assessment of risk, using strategies tailored to address its changing determinants, is an essential part of the management of acute coronary syndromes and must be applied at an early stage to identify successfully patients with most to benefit. Recognition of this fact has rendered obsolete old arguments about the appropriate timing of stress testing and other non-invasive tests which must be performed as early as possible (certainly before discharge) to be of significant value for risk stratification.

Figure 1

Recurrent ischaemic events in the first six months after acute myocardial infarction (unpublished data of …

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