Article Text

Download PDFPDF

Intravascular radiotherapy: restenosis and more?
  1. PAUL WEXBERG,
  2. MICHAEL GOTTSAUNER-WOLF
  1. Department of Cardiology, Clinic for Internal Medicine II
  2. University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna Austria
  3. email: pwexberg@pop3.kard.akh-wien.ac.at

    Statistics from Altmetric.com

    At the end of the 1970s balloon angioplasty emerged as a new hope in the treatment of coronary atherosclerosis.1 A decade later, the implantation of endovascular stents2 did not only reduce the number of acute complications of percutaneous coronary interventions, but also the incidence of restenosis.3 Now, as we begin the new millennium, intravascular radiotherapy promises to lower the restenosis rate further and has been shown to be especially effective in treatment of in-stent restenosis.4

    Restenosis develops as a response to injury, mediated by a complex interaction of an inflammatory process, thrombus formation, proliferation and migration of smooth muscle cells (SMCs), expression of growth factors, matrix synthesis, and finally vascular remodelling.5 The antiproliferative effects of ionising radiation, which are widely used in treating various benign and malignant proliferative diseases, are based on the interaction of primary (β radiation) or secondary (γ radiation) electrons with biochemical bonds in cellular DNA,6 and on subsequent changes in gene expression that finally lead to a reduction of cell growth. In cell culture …

    View Full Text

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.