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Clinical trials in cardiovascular medicine: are we looking for statistical significance or clinical relevance?
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    Application of clinical trial results

    Dear Editor:

    I read with interest Kübler’s review[1] and Willenheimer and colleagues’ viewpoint[2] on a similar theme about the application of drug trial results in clinical practice, an area that remains controversial.

    Florey’s penicillin trial in the 1940s only involved 8 mice. The mice were inoculated with streptococci and only the four that were treated survived. Such simplistic demonstration of a positive...

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    Conflict of Interest:
    None declared.