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Angiographic assessment of prospectively determined non-invasive reperfusion indices in acute myocardial infarction
  1. A J Oude Ophuisa,
  2. F W Bärb,
  3. F Vermeerb,
  4. W Janssenb,
  5. P A Doevendansb,
  6. R J Haestb,
  7. W R Dassenb,
  8. H J J Wellensb
  1. aDepartment of Cardiology, Canisius-Wilhelmina Hospital, PO Box 9015, 6500 GS Nijmegen, Netherlands, bDepartment of Cardiology, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, Netherlands
  1. Dr Oude Ophuis email: ton{at}


OBJECTIVE To investigate the value of non-invasive reperfusion indices in acute myocardial infarction, avoiding the possible need for acute coronary angiography and subsequent angioplasty.

DESIGN In a prospective angiographic study, seven potential ECG or clinical markers of reperfusion were analysed in 230 patients with acute myocardial infarction. In all patients two 12 lead ECGs were used: the ECG on admission and the ECG immediately before coronary angiography. Non-invasive markers of reperfusion determined just before coronary angiography were prospectively correlated to thrombolysis in myocardial infarction (TIMI) flow. Data analysis correlated these non-invasive indices with coronary flow (analysis A: TIMI 2–3 v TIMI 0–1 flow; analysis B: TIMI 3v TIMI 0–2 flow).

RESULTS A sudden decrease in chest pain was the most common sign of reperfusion (36%), followed by reduction in ST segment elevation by ⩾ 50% (30%), and the development of a terminal negative T wave (20%) in the lead with the highest ST segment elevation. Reduction in ST segment elevation by ⩾ 50% and the appearance of an accelerated idioventricular rhythm (AIVR) had the highest positive predictive value for reperfusion. For analyses A and B, the positive predictive values were 85% and 66% for resolution of ST segment elevation, and 94% and 59% for AIVR, respectively. The presence of three or more non-invasive markers of reperfusion predicted TIMI 3 flow accurately in 80% of cases.

CONCLUSIONS The prospective use of non-invasive indices of reperfusion is simple, practical, and can be of value in assessing coronary patency in patients admitted with acute myocardial infarction. Using these indices, discrimination between TIMI 0–1 and TIMI 2–3 flow can be made with good accuracy. However, TIMI 3 flow cannot be determined reliably. The use of such non-invasive indices depends on the goal of reperfusion.

  • reperfusion indices
  • acute myocardial infarction

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