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Increased serum concentrations of advanced glycation end products: a marker of coronary artery disease activity in type 2 diabetic patients
  1. K Kiuchi,
  2. J Nejima,
  3. T Takano,
  4. M Ohta,
  5. H Hashimoto
  1. Intensive and Coronary Care Unit and the First Department of Internal Medicine, Nippon Medical School, Tokyo 113-8603, Japan
  1. Dr Kiuchiccu{at}nms.ac.jp

Abstract

OBJECTIVE To assess whether the concentrations of serum advanced glycation end products (AGE) in diabetic patients with obstructive coronary artery disease differ from those in type 2 diabetic patients without obstructive coronary artery disease.

DESIGN Serum AGE concentrations were measured in type 2 diabetic patients and in non-diabetic patients, both with and without obstructive coronary artery disease, and the relation between these values and coronary disease severity was evaluated.

RESULTS Mean (SD) serum AGE concentrations were higher (p < 0.0125) in type 2 diabetic patients with obstructive coronary artery disease (5.5 (2.5) mU/ml, n = 30) than in patients without obstructive coronary artery disease (2.8 (0.5) mU/ml, n = 12), and higher than in non-diabetic patients with (3.4 (1.0) mU/ml, n = 28) and without (3.2 (0.4) mU/ml, n = 13) obstructive coronary artery disease. Serum AGE was associated with the degree of coronary arteriosclerosis in type 2 diabetic patients with obstructive coronary artery disease (single vessel: n = 13, 3.4 (0.9) mU/m; two vessel: n = 6, 5.7 (1.6) mU/m; three vessel: n = 11, 7.2 (2.5) mU/ml). Serum AGE was positively correlated with serum mean four year HbA1C(r = 0.46, p < 0.01), but not with recent serum HbA1C (r = 0.24). The four groups did not differ in the other coronary risk factors.

CONCLUSIONS Serum AGE concentrations may be associated with long term poor glycaemic control and reflect the severity of coronary arteriosclerosis in type 2 diabetic patients.

  • advanced glycation end products
  • non-insulin dependent diabetes
  • coronary artery disease

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