Article Text

Download PDFPDF
Serious adverse events experienced by patients with chronic heart failure taking spironolactone
  1. C Berry,
  2. J J V McMurray
  1. Department of Cardiology, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, UK
  1. Dr Berrycolin.berry{at}


In patients with chronic heart failure, spironolactone added to conventional treatment may lead to serious and, occasionally, fatal hyperkalaemia. In some cases this seems to happen because spironolactone causes diarrhoea. Four cases involving men with New York Heart Association functional class III heart failure are presented. As these cases revealed, close monitoring of blood chemistry is mandatory after starting spironolactone, and patients should be advised to stop spironolactone immediately if diarrhoea develops.

  • spironolactone
  • heart failure
  • hyperkalaemia

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.