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Treadmill exercise in apparently asymptomatic aortic stenosis
  1. Valve Study Group
  2. Cardiothoracic Centre
  3. Guy's and St Thomas' Hospitals
  4. Lambeth Palace Road
  5. St Thomas' Hospital
  6. London SE1 7EH, UK
  7. johnchambers{at}

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In the absence of symptoms, the risk of sudden death in severe aortic stenosis is said to be lower than the risks associated with valve replacement.1-3 By contrast, without surgery, the median survival is 4.5 years with angina, 2.6 years with syncope, and less than 1 year with heart failure.4 The problem is that a proportion of these deaths occur early after the onset of symptoms. Unless investigation and surgery can be performed very quickly, death, whether sudden or not, is still unacceptably common in severe aortic stenosis.

The reported cumulative risk of sudden death varies between 0–9%,4 5 and the figure of 6% in the article in this issue of Heart 6 does not appear unrepresentative in comparison with earlier data.7 8 It is possible that some of these patients had symptoms that went unrecognised, but even in studies designed with careful follow up, the mortality is 3–4% very soon after the onset of symptoms.5 9 10 Furthermore, a mortality of 7% has been reported early on a surgical waiting list.11 Therefore, the risk of an individual patient with “presymptomatic” severe aortic stenosis dying before surgery can be performed could be as high as 12% (allowing 5% for death either suddenly or soon after the onset of symptoms and a further 7% for death on the surgical waiting list). By contrast the mortality from isolated aortic valve replacement in a fit subject should be around 1–2%.12

Surgery for “presymptomatic” aortic stenosis

A reasonable conclusion is that patients should be offered surgery when “presymptomatic”, defined, for example, by a rapid increase in gradient on serial echocardiograms9. Series reporting a low risk of sudden death include many patients operated for high gradient alone or decreased exercise ability without overt symptoms,9 13 both class IIb indications according to the American Heart Association/American College of Cardiology guidelines.1 The division into symptomatic and asymptomatic is inevitably arbitrary since breathlessness may be non-specific and normal, or exertion limiting and clinically important. Exercise testing aids this distinction and may also predict the onset of a cardiac event.

Chest pain or dizziness occurred on exercise in 20 (30%) patients in the study by Amato and colleagues,6 all of whom developed spontaneous symptoms during the course of follow up. We have also shown overt symptoms in a similar proportion of patients with apparently asymptomatic severe aortic stenosis.14 15 In Amato's paper,6 exercise testing was better than echocardiographic measures of valve stenosis at predicting sudden death or the future development of symptoms. Otto and colleagues13 found the converse but included patients with less severe aortic stenosis which inevitably weighted the statistics in favour of peak transaortic velocity. However, Amato and colleagues' objective end points—ST segment depression of 2 mm or more and failure of the blood pressure to rise more than 20 mm Hg during exercise—are probably too sensitive since the test was positive in most patients (67%) and the mean time to an event was eight months. All patients with severe aortic stenosis die prematurely given a long enough follow up4and the aim is to predict an imminent not an ultimate event. Otto and colleagues13 found that a fall in systolic blood pressure by 10 mm Hg was a univariate predictor of progression to surgery and this may be a better threshold. It is also possible that a reproducible decline in exercise time on serial testing should be an indication for prophylactic surgery, but as yet this remains unproven.

Safety of exercise testing

Severe aortic stenosis has traditionally been regarded as a contraindication to exercise testing, and even asymptomatic moderate stenosis as a relative contraindication.16 However, testing is safe as long as it uses a protocol such as the modified Bruce, and is symptom limited.6 13-15 Exercise should be performed if the valve area is 1.0 cm2 or less, which includes moderate as well as severe aortic stenosis. This is because the presence of symptoms depends on left ventricular function, coronary flow, and the peripheral circulation as well as the grade of valvar obstruction.17 18 Thus we showed14 that 11% of apparently asymptomatic patients with moderate stenosis (valve area 0.75–1.0 cm2) had symptoms on exercise testing compared with 25% with severe stenosis (valve area < 0.75 cm2) and none with an area above 1.0 cm2. Exercise testing should probably be repeated every six months for severe aortic stenosis and every year for moderate stenosis based on known rates of progression.13

The difference in prognosis between genuinely asymptomatic and symptomatic aortic stenosis is extreme and assessment should not be left to subjective history taking alone. Exercise testing reveals symptoms in a sizeable proportion of apparently asymptomatic patients with moderate or severe aortic stenosis and we believe should be performed routinely before assigning a patient to continued conservative treatment. The clinical use of other exercise related end points to guide prophylactic surgery is intuitively attractive but not yet established.