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Prognostic significance of cardiac 123I metaiodobenzylguanidine imaging for mortality and morbidity in patients with chronic heart failure: a prospective study
  1. H Ogitaa,
  2. T Shimonagataa,
  3. M Fukunamia,
  4. K Kumagaia,
  5. T Yamadaa,
  6. Y Asanoa,
  7. A Hirataa,
  8. M Asaia,
  9. H Kusuokab,
  10. M Horic,
  11. N Hokia
  1. aDivision of Cardiology, Osaka Prefectural General Hospital, 3-1-56 Mandai-Higashi Sumiyoshi-ku, Osaka 558-8558, Japan, bDivision of Clinical Investigation, Osaka National Hospital, Osaka, Japan, cDepartment of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan
  1. Dr H Ogita, Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita 565-0871, Japanhogita{at}


OBJECTIVE To determine whether cardiac iodine-123 metaiodobenzylguanidine (123I MIBG) imaging is useful in predicting the prognosis of patients with chronic heart failure.

DESIGN Cardiac 123I MIBG imaging was done on entry to the study. The cardiac MIBG washout rate was calculated from anterior chest view images obtained 20 and 200 minutes after injection of the isotope. Study patients were divided into two groups with washout rates above and below 27% (the mean value + 2 SD obtained in 20 normal subjects), and were then followed up.

SETTING Tertiary referral centre.

PATIENTS 79 patients with chronic heart failure in whom the left ventricular ejection fraction was less than 40%.

RESULTS There were 37 patients in group 1 (washout rate of ⩾ 27%) and 42 in group 2 (< 27%). During a follow up period of between 1 and 52 months, eight patients died suddenly and five died of worsening heart failure in group 1, while none died in group 2; 13 patients in group 1 and four in group 2 were admitted to hospital for progressive heart failure. Kaplan–Meier analysis showed that group 1 had a significantly higher mortality and morbidity (p = 0.001 and p < 0.001, respectively) than group 2.

CONCLUSIONS Cardiac 123I MIBG washout rate seems to be a good predictor of prognosis in patients with chronic heart failure.

  • chronic heart failure
  • sudden death
  • cardiac adrenergic nerve activity

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