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Review
Inflammation in acute coronary syndromes
  1. N T Mulvihill,
  2. J B Foley
  1. Department of Cardiology, St James's Hospital, Dublin 8, Republic of Ireland
  1. Correspondence to:
    Dr N T Mulvihill, Unité de Cardiologie Interventionnelle, Clinique Pasteur, 45 Avenue de Lombez, 31076 Toulouse, France;
    mulvihin{at}hotmail.com

Abstract

Extensive evidence supports a pathogenic role for both local and systemic inflammation in acute coronary syndromes. However, several important questions remain unanswered. Is the observed inflammatory process a precursor or a consequence of coronary plaque rupture? Is the inflammatory component of unstable coronary disease a potential therapeutic target? Finally, do infectious agents have a pathogenic role in coronary atherosclerosis and acute coronary syndromes?

  • acute coronary syndromes
  • atherosclerosis
  • inflammation
  • plaque
  • CMV, cytomegalovirus
  • CRP, C reactive protein
  • ICAM-1, intercellular adhesion molecule-1
  • NF-κB, nuclear factor κB
  • VCAM-1, vascular cell adhesion molecule-1

https://doi.org/10.1136/heart.87.3.201

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