Extensive evidence supports a pathogenic role for both local and systemic inflammation in acute coronary syndromes. However, several important questions remain unanswered. Is the observed inflammatory process a precursor or a consequence of coronary plaque rupture? Is the inflammatory component of unstable coronary disease a potential therapeutic target? Finally, do infectious agents have a pathogenic role in coronary atherosclerosis and acute coronary syndromes?
- acute coronary syndromes
- CMV, cytomegalovirus
- CRP, C reactive protein
- ICAM-1, intercellular adhesion molecule-1
- NF-κB, nuclear factor κB
- VCAM-1, vascular cell adhesion molecule-1
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