Genetic polymorphisms in the renin-angiotensin-aldosterone system associated with expression of left ventricular hypertrophy in hypertrophic cardiomyopathy: a study of five polymorphic genes in a family with a disease causing mutation in the myosin binding protein C gene

J R Ortlepp; H P Vosberg; S Reith; F Ohme; N G Mahon; D Schröder; H G Klues; P Hanrath; W J McKenna

doi:10.1136/heart.87.3.270

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Genetic polymorphisms in the renin-angiotensin-aldosterone system associated with expression of left ventricular hypertrophy in hypertrophic cardiomyopathy: a study of five polymorphic genes in a family with a disease causing mutation in the myosin binding protein C gene

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	Abstract	Full	Pdf
Feb 2002	46	88	38
Mar 2002	28	97	24
Apr 2002	14	69	18
May 2002	5	56	774
Jun 2002	6	42	9
Jul 2002	15	32	13
Aug 2002	6	24	10
Sep 2002	5	45	28
Oct 2002	5	54	30
Nov 2002	10	34	20
Dec 2002	21	38	17
Jan 2003	9	13	8
Feb 2003	9	40	22
Mar 2003	3	21	11
Apr 2003	3	37	23
May 2003	14	22	4
Jun 2003	4	10	4
Jul 2003	20	43	11
Aug 2003	23	20	7
Sep 2003	16	25	4
Oct 2003	30	45	11
Nov 2003	28	28	12
Dec 2003	24	18	3
Jan 2004	27	17	8
Feb 2004	10	21	2
Mar 2004	29	27	12
Apr 2004	36	34	16
May 2004	48	50	14
Jun 2004	50	64	15
Jul 2004	47	64	17
Aug 2004	47	64	25
Sep 2004	35	46	10
Oct 2004	25	49	8
Nov 2004	19	60	29
Dec 2004	20	63	34
Jan 2005	23	58	34
Feb 2005	13	47	24
Mar 2005	14	34	17
Apr 2005	4	38	13
May 2005	10	42	14
Jun 2005	10	23	17
Jul 2005	9	20	3
Aug 2005	11	41	15
Sep 2005	15	26	16
Oct 2005	19	37	19
Nov 2005	13	34	18
Dec 2005	16	28	11
Jan 2006	15	34	6
Feb 2006	10	46	15
Mar 2006	22	48	17
Apr 2006	8	34	15
May 2006	6	20	14
Jun 2006	3	12	5
Jul 2006	4	12	7
Aug 2006	3	16	8
Sep 2006	4	26	9
Oct 2006	6	48	18
Nov 2006	7	37	17
Dec 2006	6	30	13
Jan 2007	4	17	9
Feb 2007	2	30	10
Mar 2007	7	29	20
Apr 2007	13	7	5
May 2007	11	8	7
Jun 2007	8	14	8
Jul 2007	11	10	10
Aug 2007	5	1	6
Sep 2007	5	5	6
Oct 2007	16	8	8
Nov 2007	11	3	3
Dec 2007	12	4	7
Jan 2008	0	4	4
Feb 2008	15	10	3
Mar 2008	18	7	8
Apr 2008	22	7	9
May 2008	43	6	5
Jun 2008	31	3	3
Jul 2008	18	6	5
Aug 2008	18	7	3
Sep 2008	47	6	5
Oct 2008	23	5	5
Nov 2008	21	7	2
Dec 2008	12	4	0
Jan 2009	15	4	3
Feb 2009	9	10	3
Mar 2009	14	13	2
Apr 2009	12	9	1
May 2009	4	15	5
Jun 2009	10	9	4
Jul 2009	12	17	3
Aug 2009	12	8	4
Sep 2009	19	9	2
Oct 2009	16	9	2
Nov 2009	18	8	3
Dec 2009	32	4	4
Jan 2010	192	4	5
Feb 2010	146	0	1
Mar 2010	153	4	4
Apr 2010	159	7	5
May 2010	146	1	1
Jun 2010	85	4	7
Jul 2010	48	3	6
Aug 2010	132	23	18
Sep 2010	260	52	60
Oct 2010	112	24	29
Nov 2010	20	6	2
Dec 2010	19	5	2
Jan 2011	14	0	1
Feb 2011	18	4	6
Mar 2011	23	13	4
Apr 2011	23	5	5
May 2011	44	23	19
Jun 2011	12	4	2
Jul 2011	14	2	2
Aug 2011	21	7	3
Sep 2011	22	9	5
Oct 2011	25	3	8
Nov 2011	29	12	6
Dec 2011	19	20	13
Jan 2012	20	13	5
Feb 2012	19	16	8
Mar 2012	17	12	11
Apr 2012	14	13	6
May 2012	14	21	19
Jun 2012	12	14	24
Jul 2012	21	13	34
Aug 2012	17	3	39
Sep 2012	27	4	25
Oct 2012	15	6	39
Nov 2012	38	31	39
Dec 2012	74	58	10
Jan 2013	21	16	8
Feb 2013	47	22	7
Mar 2013	58	19	3
Apr 2013	25	3	5
May 2013	25	4	3
Jun 2013	28	9	2
Jul 2013	11	6	2
Aug 2013	25	0	0
Sep 2013	82	7	1
Oct 2013	94	33	3
Nov 2013	71	18	2
Dec 2013	26	4	0
Jan 2014	9	8	4
Feb 2014	9	0	1
Mar 2014	14	4	1
Apr 2014	12	4	4
May 2014	8	3	1
Jun 2014	8	9	2
Jul 2014	21	10	5
Aug 2014	4	5	1
Sep 2014	6	7	1
Oct 2014	12	2	4
Nov 2014	10	2	3
Dec 2014	8	4	1
Jan 2015	11	1	3
Feb 2015	3	1	3
Mar 2015	12	9	3
Apr 2015	11	1	4
May 2015	12	5	1
Jun 2015	5	4	2
Jul 2015	5	2	0
Aug 2015	4	5	5
Sep 2015	26	8	1
Oct 2015	7	6	0
Nov 2015	10	0	3
Dec 2015	7	2	1
Jan 2016	4	4	4
Feb 2016	17	2	4
Mar 2016	10	1	2
Apr 2016	15	8	15
May 2016	26	2	7
Jun 2016	9	3	4
Jul 2016	6	2	2
Aug 2016	10	2	2
Sep 2016	6	5	3
Oct 2016	9	0	3
Nov 2016	8	9	4
Dec 2016	12	4	3
Jan 2017	5	3	3
Feb 2017	5	7	1
Mar 2017	5	9	3
Apr 2017	2	5	3
May 2017	3	22	4
Jun 2017	13	20	9
Jul 2017	29	27	1
Aug 2017	16	8	2
Sep 2017	14	10	1
Oct 2017	6	4	1
Nov 2017	14	8	0
Dec 2017	11	5	3
Jan 2018	18	12	3
Feb 2018	12	8	1
Mar 2018	13	7	0
Apr 2018	16	8	0
May 2018	20	14	1
Jun 2018	28	24	1
Jul 2018	39	21	2
Aug 2018	19	11	2
Sep 2018	15	9	1
Oct 2018	9	7	5
Nov 2018	8	6	3
Dec 2018	13	7	1
Jan 2019	8	6	0
Feb 2019	21	15	4
Mar 2019	11	8	4
Apr 2019	11	3	5
May 2019	12	6	2
Jun 2019	2	2	9
Jul 2019	7	5	7
Aug 2019	4	4	6
Sep 2019	15	13	3
Oct 2019	6	6	3
Nov 2019	10	9	3
Dec 2019	11	3	3
Jan 2020	11	11	4
Feb 2020	13	11	5
Mar 2020	5	4	4
Apr 2020	7	1	3
May 2020	10	8	3
Jun 2020	7	6	2
Jul 2020	18	11	3
Aug 2020	6	6	3
Sep 2020	20	15	4
Oct 2020	13	9	8
Nov 2020	11	9	3
Dec 2020	21	13	4
Jan 2021	22	18	6
Feb 2021	11	7	4
Mar 2021	10	9	1
Apr 2021	9	9	5
May 2021	4	4	1
Jun 2021	4	4	3
Jul 2021	2	2	6
Aug 2021	7	7	10
Sep 2021	5	5	9
Oct 2021	6	4	15
Nov 2021	10	6	16
Dec 2021	8	6	4
Jan 2022	14	10	6
Feb 2022	17	6	5
Mar 2022	21	3	1
Apr 2022	4	4	7
May 2022	12	10	12
Jun 2022	22	20	5
Jul 2022	26	12	5
Aug 2022	55	42	4
Sep 2022	2	2	5
Oct 2022	9	7	10
Nov 2022	17	12	3
Dec 2022	10	6	1
Jan 2023	12	10	9
Feb 2023	34	36	2
Mar 2023	8	6	2
Apr 2023	7	3	4
May 2023	8	5	8
Jun 2023	15	8	5
Jul 2023	6	4	6
Aug 2023	4	4	62
Sep 2023	13	13	232
Oct 2023	17	17	6
Nov 2023	39	33	10
Dec 2023	149	22	2
Jan 2024	28	0	4
Feb 2024	75	0	0
Mar 2024	100	4	1
Total	5852	4124	3082

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