Article Text

Download PDFPDF
Acquired von Willebrand syndrome in children with patent ductus arteriosus
  1. R Rauch1,
  2. U Budde2,
  3. A Koch3,
  4. M Girisch3,
  5. M Hofbeck1
  1. 1University Children's Hospital, Tuebingen, Germany
  2. 2Labor Keeser-Arndt, Hamburg, Germany
  3. 3University Children's Hospital, Erlangen-Nuernberg, Germany
  1. Correspondence to:
    Dr Ralf Rauch, University Children's Hospital, Department of Cardiology, Hoppe-Seyler-Strasse 3, D-72076 Tuebingen, Germany;

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Since acquired von Willebrand syndrome (AVWS) was first described in 1968, approximately 270 cases have been reported in the literature. In 12% of these cases AVWS was secondary to cardiovascular disorders.1 Only two of these reports dealt with children.2,3 Gill and colleagues reported on 12 patients with non-cyanotic heart defects (atrial and ventricular septal defects, aortic stenosis) and abnormal von Willebrand factor (VWF) subunits.2 Four out of five patients with ventricular septal defect who underwent repeat examination following surgical repair showed normalisation of the multimeric pattern.

We recently described the first case of AVWS in an infant with persistently patent ductus arteriosus (PDA).3 To study the frequency of this association and its aetiology, we examined 12 children (eight girls, four boys, median age 3.4 years) …

View Full Text