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Perindopril improves six minute walking distance in older patients with left ventricular systolic dysfunction: a randomised double blind placebo controlled trial
  1. S D Hutcheon1,
  2. N D Gillespie1,
  3. I K Crombie2,
  4. A D Struthers3,
  5. M E T McMurdo1
  1. 1Section of Ageing & Health, Department of Medicine, University of Dundee, Ninewells Hospital, Dundee, UK
  2. 2Department of Epidemiology and Public Health, University of Dundee
  3. 3Department of Clinical Pharmacology, University of Dundee
  1. Correspondence to:
    Professor MET McMurdo, Section of Ageing & Health, Department of Medicine, Ninewells Hospital, Dundee DD1 9SY;


Objective: To evaluate the effects of the angiotensin converting enzyme inhibitor perindopril on six minute walking distance and quality of life in very old patients with left ventricular systolic dysfunction.

Design: Prospective, double blind placebo controlled trial.

Setting: Medicine for the elderly day hospital.

Patients: 66 patients (average age 81) with left ventricular systolic dysfunction identified by echocardiography.

Interventions: 10 weeks of treatment with titrated doses of perindopril or placebo.

Main outcome measures: Six minute walking distance 10 weeks following treatment, quality of life measurements including the Minnesota living with heart failure questionnaire and the 36 item short form health survey.

Results: In patients with left ventricular systolic dysfunction, six minute walking distance was significantly increased in the treatment group (37.1 m) compared with the placebo group (−0.3 m, p < 0.001). The medication was well tolerated and there were no significant adverse events.

Conclusions: Six minute walking distance is improved considerably by treatment with perindopril in older patients with heart failure caused by left ventricular systolic dysfunction.

  • heart failure
  • six minute walking distance
  • elderly
  • quality of life
  • perindopril
  • tolerability
  • CANTAB, Cambridge neuropsychological test automated battery
  • LIhFE, Minnesota living with heart failure
  • NYHA, New York Heart Association
  • SF-36, 36 item short form

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