Article Text

Download PDFPDF

Early prediction of improvement in ejection fraction after acute myocardial infarction using low dose dobutamine echocardiography
  1. F Nijland1,
  2. O Kamp1,
  3. P M J Verhorst1,
  4. W G de Voogt2,
  5. C A Visser1
  1. 1Department of Cardiology and Institute for Cardiovascular Research, VU Medical Centre, Amsterdam, Netherlands
  2. 2Department of Cardiology, Sint Lucas-Andreas Hospital, Amsterdam
  1. Correspondence to:
    Dr Francisca Nijland, VU Medical Centre, Department of Cardiology, PO Box 7057, 1007 MB Amsterdam, Netherlands;
    fr.nijland{at}12move.nl

Abstract

Objective: To evaluate the relation between changes in ejection fraction during the first three months after acute myocardial infarction and myocardial viability.

Patients: Myocardial viability was assessed using low dose dobutamine echocardiography in 107 patients at mean (SD) 3 (1) days after acute myocardial infarction. Cross sectional echocardiography was repeated three months later. Left ventricular volumes and ejection fraction were determined from apical views using the Simpson biplane formula.

Results: In patients with viability, ejection fraction increased by 4.4 (4.3)%; in patients without viability it remained unchanged (0.04 (3.6)%; p < 0.001). A ≥ 5% increase in ejection fraction was present in 21 of 107 patients (20%). Receiver operating characteristic analysis showed that myocardial viability in ≥ 2 segments predicted this increase in ejection fraction with a sensitivity of 81% and a specificity of 65%. Multivariate logistic regression analysis was used to define which clinical and echocardiographic variables were related to ≥ 5% improvement in ejection fraction. Myocardial viability, non-Q wave infarction, and anterior infarction all emerged as independent predictors, myocardial viability being the best (χ2 = 14.5; p = 0.0001). Using the regression equation, the probability of ≥ 5% improvement in ejection fraction for patients with a non-Q wave anterior infarct with viability was 73%, and for patients with a Q wave inferior infarct without viability, only 2%.

Conclusions: Myocardial viability after acute myocardial infarction is the single best predictor of improvement in ejection fraction. In combination with infarct location and Q wave presence, the probability of ≥ 5% improvement can be estimated in individual patients at the bedside.

  • echocardiography
  • myocardial infarction
  • myocardial viability
View Full Text

Statistics from Altmetric.com

Footnotes

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.