Article Text

Download PDFPDF
Angiogenesis, thrombogenesis, endothelial dysfunction and angiographic severity of coronary artery disease
  1. N A Chung,
  2. C Lydakis,
  3. F Belgore,
  4. F L Li-Saw-Hee,
  5. A D Blann,
  6. G Y H Lip
  1. Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
  1. Correspondence to:
    Professor G Y H Lip
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK; g.y.h.lipbham.ac.uk

Abstract

Background: Thrombogenesis, angiogenesis, and endothelial damage/dysfunction are components in the pathogenesis of atherosclerosis.

Objective: To investigate the relation of these variables to atherosclerotic disease severity and the possible interrelations between the three.

Methods: 111 patients attending for coronary angiography were studied (85 male, 26 female; mean (SD) age, 61.6 (10.0) years). Plasma concentrations of von Willebrand factor (vWf, a marker of endothelial damage/dysfunction), vascular endothelial growth factor (VEGF, associated with angiogenesis), soluble VEGF receptor Flt-1 (sFlt-1), and tissue factor (TF, a key component of coagulation) were measured by an enzyme linked immunosorbent assay. Following angiography, disease severity was assessed by the number of coronary vessels diseased (> 50% stenosis) and by a coronary atheroma score.

Results: All indices were raised in the patients compared with 34 healthy controls except sFlt-1, which was lower in the patients. No significant correlations were found between the coronary atheroma score and values of vWf (Spearman correlations: r  =  0.21, p  =  0.83), VEGF (r  =  0.11, p = 0.27), or TF (r  =  −0.04, p  =  0.68). However, there was an inverse correlation between plasma sFlt-1 and coronary atheroma score (r  =  −0.19, p  =  0.049). The number of vessels diseased had no relation to any marker. Correlations were found between TF and VEGF (r  =  0.25, p  =  0.008) and between TF and sFlt-1 (r  =  0.42, p < 0.001) in the patients.

Conclusions: Despite evidence of abnormal angiogenesis (VEGF and sFlt-1), thrombogenesis (TF), and endothelial damage/dysfunction (vWf) in the patients with coronary artery disease, there was no correlation between VEGF, sFlt-1, vWf, or TF and angiographically defined disease severity.

  • angiogenesis
  • thrombogenesis
  • endothelium
  • coronary artery disease
  • sFlt-1, soluble VEGF receptor Flt-1
  • TF, tissue factor
  • VEGF, vascular endothelial growth factor
  • VWf, von Willebrand factor

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Footnotes